Natural killer cells in rejection and tolerance of solid organ allografts
نویسندگان
چکیده
منابع مشابه
The beginning of clinical tolerance in solid organ allografts.
Development of effective multidrug immunosuppressive regimens and improvements in the management of chronically immunosuppressed patients have produced extraordinary patient and allograft survival in clinical organ transplantation. Unfortunately, significant problems of morbidity and mortality related to chronic immunosuppression remain. Thus, there is an enormous motivation and interest in ind...
متن کاملHumoral rejection of organ allografts.
In recent years, the deleterious clinical consequences of recipient de novo alloantibody production against HLA antigens from human organ allografts have been extensively investigated. In kidney transplantation, the identification of the complement C4d fragment in peritubular capillaries as a specific marker for humoral rejection has helped to define and characterize distinct clinical alloantib...
متن کاملImmunosuppressive therapy and tolerance of organ allografts.
Moses JW, Leon MB, Popma JJ, et al. Sirolimus-eluting stents versus standard stents in patients with stenosis in a native coronary artery. N Engl J Med 2003;349:1315-23. Stone GW, Ellis SG, Cox DA, et al. A polymer-based, paclitaxel-eluting stent in patients with coronary artery disease. N Engl J Med 2004;350:221-31. Pfisterer M, Brunner-La Rocca HP, Buser PT, et al. Late clinical events after ...
متن کاملThe Role of Natural Killer Cells in Human Solid Organ and Tissue Transplantation
During the last decade, considerable progress was made in the understanding of the natural killer (NK) cell mechanisms of action, especially in the processes of target cell recognition and lysis. These breakthroughs have aroused large interest in the role of NK cells in the pathogenesis of a variety of diseases. In hematopoietic stem cell transplantation, NK cells have been shown to play a sign...
متن کاملThe Role of Natural Killer Cells in Human Solid Organ and Tissue Transplantation
During the last decade, considerable progress was made in the understanding of the natural killer (NK) cell mechanisms of action, especially in the processes of target cell recognition and lysis. These breakthroughs have aroused large interest in the role of NK cells in the pathogenesis of a variety of diseases. In hematopoietic stem cell transplantation, NK cells have been shown to play a sign...
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ژورنال
عنوان ژورنال: Current Opinion in Organ Transplantation
سال: 2011
ISSN: 1087-2418
DOI: 10.1097/mot.0b013e32834254cf